SKIN BOOSTER · PLINEST

Plinest: PN-HPT Polynucleotide Booster — Istanbul

Plinest is a polynucleotide skin booster made by Mastelli in Sanremo, Italy, from highly purified DNA fragments (PN-HPT). It is used to improve skin texture, elasticity and hydration, not to add volume. Veneta in Nişantaşı offers Plinest after a skin assessment by a physician.

Last updated: October 2026

At a Glance

Type

Polynucleotide (PN-HPT) skin booster

Manufacturer

Mastelli, Italy

Sessions

Usually 3–4, every 2–3 weeks

Results last

No manufacturer figure; one study reported benefits up to about 6 months

Downtime

Brief redness; small bruises possible

What Is Plinest?

Plinest contains PN-HPT (polynucleotides highly purified technology): long DNA chains purified from trout gonads. Standard Plinest (20 mg/ml) is a CE-marked class III medical device for the face, neck and décolletage.

In the dermis, the DNA fragments form a viscoelastic gel that hydrates and is thought to support the skin’s own repair, so results build over a course.

Plinest Products

Product	What it is	Typical use
Plinest	PN-HPT 20 mg/ml, 2 ml syringe	Face: younger skin and acne scars
Plinest Eye	PN-HPT 7.5 mg/ml	Eye contour
Plinest Hair	PN-HPT 7.5 mg/ml	Scalp and eyebrows
Plinest Fast	PN-HPT gel	Sensitive, delicate skin areas
Newest	PN-HPT and hyaluronic acid (20 mg each per 2 ml) with mannitol	Dehydrated, mature skin; face, neck, décolletage
Plinest One, Newest One	4 ml vials	Body stretch marks and depressed scars

Who Plinest Suits

Early ageing on the face, neck, décolletage or hands, without added volume.
Crêpey skin around the eyes, with Plinest Eye.
Acne scars, and body stretch marks (Plinest One, Newest One).
Thinning hair or eyebrows, with Plinest Hair.
Not suitable in pregnancy or breastfeeding, or with an active infection at the site or a fish allergy; blood thinners need a physician’s review.

How the Treatment Works at Veneta

Skin assessment

A physician examines your skin, asks about allergies (including fish) and medicines, and chooses the product.

Preparation

The skin is cleansed and disinfected; a numbing cream can be applied.

Micro-injections

Small droplets or thin lines of gel are placed in the dermis with a fine 30–32G needle; for the face, the whole 2 ml syringe is usually used.

Aftercare and follow-up

Redness, mild burning or small bruises settle quickly; avoid direct sun for 48 hours. Next session: 2–3 weeks later.

Skin Boosters: Average Prices in Istanbul

Average Istanbul market prices compiled in October 2026, for orientation. The price of a specific product is confirmed after your consultation.

Treatment	Unit	Average price	Typical range
Classic medical facial	per session	3,000 TRY≈ €55	2,000–5,000 TRY≈ €35–€90
Chemical peel (superficial to medium)	per session	4,000 TRY≈ €70	2,500–7,500 TRY≈ €45–€135
Carbon laser peel	per session	2,500 TRY≈ €45	1,500–5,000 TRY≈ €25–€90
Skin booster (injectable hyaluronic acid)	per session, face	15,000 TRY≈ €270	10,000–25,000 TRY≈ €180–€450
Profhilo	per session, 2 ml	20,000 TRY≈ €360	15,000–25,000 TRY≈ €270–€450
Salmon DNA / polynucleotides (PDRN)	per session	6,000 TRY≈ €105	2,500–11,500 TRY≈ €45–€205
Facial mesotherapy	per session	5,000 TRY≈ €90	3,000–9,000 TRY≈ €55–€160
PRP for the face	per session	8,000 TRY≈ €145	5,000–12,000 TRY≈ €90–€215
Exosome treatment — face	per session	15,000 TRY≈ €270	10,000–25,000 TRY≈ €180–€450
IPL (Lumecca) — face	per session	10,000 TRY≈ €180	5,000–15,000 TRY≈ €90–€270
Dermapen microneedling	per session, face	7,000 TRY≈ €125	5,000–10,000 TRY≈ €90–€180
Morpheus8 — face	per session	26,000 TRY≈ €465	20,000–35,000 TRY≈ €360–€625
HIFU — full face	per session	25,000 TRY≈ €450	15,000–35,000 TRY≈ €270–€625
Fractional CO2 laser — full face	per session	25,000 TRY≈ €450	5,000–60,000 TRY≈ €90–€1,075
Stretch mark treatment — one area	per session	15,000 TRY≈ €270	7,500–35,000 TRY≈ €135–€625

Average Istanbul prices compiled in October 2026, for orientation only. Your personal price depends on the product, the amount and the plan agreed at your consultation. Euro amounts are approximate, converted at 55.86 TRY = 1 EUR.

Plinest Compared With Other Skin Boosters

Plinest, Rejuran, Nucleofill and Vitaran all contain polynucleotides; they differ in manufacturer, DNA source, concentration and range.

PN is not the same as PDRN: PDRN consists of shorter, lower-molecular-weight DNA fragments, while PN chains are longer and form a gel in the skin. See the polynucleotide overview.

Related treatments

Frequently Asked Questions

What is Plinest?

Plinest is an injectable polynucleotide skin booster made by Mastelli in Italy from highly purified trout DNA (PN-HPT). It is used to improve skin quality, not to add volume.

How many Plinest sessions do I need?

Usually 3 Plinest sessions every 2–3 weeks for the face, and 3–4 for the eye area, neck or advanced ageing; scalp courses are longer, about 8 sessions.

How long does Plinest last?

Plinest results build over the course. Mastelli publishes no duration; one study reported patient-reported benefits lasting up to about 6 months.

Is there downtime after Plinest?

Usually little: redness, mild burning or small bumps settle within a day or two, and small bruises can occur; avoid direct sun for 48 hours.

Is Plinest PDRN?

No. Plinest contains polynucleotides (PN-HPT), longer DNA chains than PDRN; Mastelli makes both, but Plinest is PN.

This page is general information and does not replace a medical consultation. Whether Plinest suits you is decided by our physicians after a skin assessment.

Free Consultation — Plinest in Istanbul

Send us a WhatsApp message or book a video call; the consultation is free. You receive a written plan with the product, number of sessions and price before treatment.

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