Question 1

What is polynucleotide (PN) treatment?

Accepted Answer

Polynucleotides (PN-HPT, Highly Purified Technology) are high-purity nucleotide polymers isolated from salmon DNA. Plinest® (Mastelli Italy), Nucleofill® (Promoitalia) are original products. When injected into dermis, they activate fibroblasts, angiogenesis (new vessel formation), antioxidant and anti-inflammatory effects. Known as 'salmon DNA injection'. Spread in EU since 2020.

Question 2

Difference between PN and skin booster (Profhilo)?

Accepted Answer

Profhilo: pure HA bio-stimulant, provides hydration and volume sensation, 6-9 month effect. PN: salmon DNA polymers, real tissue regeneration (new collagen, elastin, angiogenesis), 12-18 month effect. PN deeper biological effect — especially for thin skin, photoaging, melasma, post-acne. Combined (Profhilo+PN) creates ultra premium protocol.

Question 3

In what conditions is polynucleotide effective?

Accepted Answer

Under-eye darkness (especially thin skin + vascular type), fine lines (perioral, periorbital), skin elasticity loss, melasma, post-acne scars, alopecia (hair loss), striae (stretch marks), neck-decolletage aging. Clinical evidence: 43% elasticity increase (12 weeks), 38% fine line reduction, 52% hydration improvement (Mastelli RCT data).

Question 4

How are PN sessions applied?

Accepted Answer

Standard protocol: 3 sessions, 2 weeks apart. Maintenance: 1 session every 6-9 months. Plinest 2-3 ml, Nucleofill 1.5-2 ml dosage. 27G needle, deep dermal level, micro-papule technique. Session 30 min, local anesthetic cream sufficient. Minimum downtime (24 hours mild redness). Cumulative effect — peaks at 4-6 weeks.

Question 5

PN treatment side effects and contraindications?

Accepted Answer

Side effects rare: 24-48 hours mild swelling/redness, micro-papule marks (1-2 days). Allergy very rare — salmon DNA is purified, no protein-based reactions. Contraindications: pregnancy, breastfeeding, active infection, autoimmune disease. Our physician personalizes protocol after medical history + skin analysis.

Question 6

How much does polynucleotide (PN) cost in 2026?

Accepted Answer

At Veneta: PN-HPT (salmon DNA) session 255 USD. 3-session package 660 USD (14% discount). Our physician personalized plan.

Question 7

Why choose Veneta for polynucleotide?

Accepted Answer

Veneta uses authentic Italian/Korean PN-HPT, MD-certified application, plastic surgeon supervision, 650+ Google reviews (5.0/5).

Question 8

Is Botox treatment safe?

Accepted Answer

Yes. We use original Allergan Botox® approved by the FDA and Turkish Ministry of Health. The procedure is performed exclusively by our physician in sterile clinical conditions.

Question 9

How long does Botox last?

Accepted Answer

On average 4-6 months. With regular sessions, the effect duration may extend and less product is needed over time.

Question 10

When does Botox start to work?

Accepted Answer

Effects begin within 3-7 days, with full results visible by day 14. You can return to daily activities immediately after the procedure.

Question 11

What should I avoid after Botox?

Accepted Answer

For the first 4 hours: do not lie flat, do not massage the area. Avoid intense exercise and heat (sauna, hammam) for 24 hours. These rules ensure the product stays in the target muscle.

Question 12

Which areas can Botox treat?

Accepted Answer

Most commonly: forehead lines, glabella (frown lines), crow's feet, masseter (jaw slimming), bunny lines (around nose) and gummy smile. Also effective for migraines and excessive sweating.

Question 13

Are there side effects of Botox?

Accepted Answer

When applied at correct doses to correct anatomical points, side effect risk is minimal. Mild redness or bruising may occur temporarily. Application by our physicians minimizes these risks.

Question 14

Can men receive Botox?

Accepted Answer

Yes. A specialized "Brotox" protocol is applied for male anatomy and muscle structure. The aim is natural, light line preservation — never a frozen or artificial look.

Question 15

What's the difference between medical skin care and regular facials?

Accepted Answer

Medical skin care is performed under physician supervision using medical devices (HydraFacial, microneedling, PRP) and active ingredients. Unlike regular facials, it provides therapeutic solutions for acne, pigmentation and wrinkles.

Question 16

How many sessions does medical skin care require?

Accepted Answer

Varies between 1-6 sessions depending on the skin issue. HydraFacial shows results from the first session; for acne or pigmentation, 4-6 sessions are recommended. Sessions are 2-4 weeks apart.

Question 17

Can sensitive skin receive medical care?

Accepted Answer

Yes. Special low-intensity protocols are applied for sensitive skin. After skin analysis, the appropriate product and device combination is determined by our physicians.

Question 18

Which treatment is suitable for which skin type?

Accepted Answer

Oily/acne skin: HydraFacial + dermapen. Dry skin: skin booster + mesotherapy. Pigmented skin: chemical peeling + PRP. Anti-aging: PRP + exosome combinations are recommended.

Question 19

How long until I can return to daily life after medical skin care?

Accepted Answer

Most treatments allow immediate return. Non-invasive procedures like HydraFacial are immediately suitable for social life. Slight redness may occur for 24-48 hours after microneedling.

Question 20

Can medical skin care be done in summer?

Accepted Answer

Yes, but sun protection is essential. Laser and peeling treatments are preferred for autumn-winter. HydraFacial and exosome treatments can be safely performed in any season.

Question 21

At what age should medical skin care begin?

Accepted Answer

25 is ideal for preventive care. Acne treatment from age 16+, anti-aging protocols from age 30+. Personalized plans are created after skin analysis.

Question 22

What is exosome therapy?

Accepted Answer

Exosomes are nano-sized bioactive vesicles released from stem cells. They contain growth factors, microRNA and proteins that support skin regeneration and hair follicle revitalization.

Question 23

How many exosome sessions are needed?

Accepted Answer

3-4 sessions for skin, 4-6 sessions for hair treatment. Sessions are 2-4 weeks apart. Initial effects are felt by session 2, lasting results become clear from month 3.

Question 24

Exosomes or PRP — which is more effective?

Accepted Answer

Exosomes contain 100-200x more growth factors than PRP. They show faster and more pronounced effects. However, combined use is also recommended depending on budget and skin condition.

Question 25

Is exosome therapy safe?

Accepted Answer

Yes. The products used are produced under GMP standards, sterile and allergen-free. As they mimic the body's natural repair process, side effect risk is very low.

Question 26

What conditions are exosomes used for?

Accepted Answer

Highly effective for hair loss, thin/sparse hair, facial aging, fine wrinkles, acne scars, skin tone loss and under-eye hollowing.

Question 27

Is exosome treatment painful?

Accepted Answer

Topical anesthetic cream is applied before the procedure. Performed via microneedling or injection; most patients report only mild tingling, no pain.

Question 28

How long do exosome results last?

Accepted Answer

Single session effect lasts 6-9 months. Full protocol (3-4 sessions) provides 12-18 months of lasting effect. Maintained with 1-2 annual sessions.

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תהליך הטיפול בפולינוקלאוטידים PN-HPT

למה פולינוקלאוטידים ב-Veneta?

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למה Veneta?

פולינוקלאוטידים באיסטנבולחידוש העור, אנטי-אייג׳ינג