MEN'S INTIMATE HEALTH · P-SHOT (PRP)

P-Shot: PRP for Men, Without the Hype — Istanbul

Q: Does the P-Shot make the penis bigger?

No. The P-Shot is not a size-enlargement treatment . Any fullness after the injections is temporary swelling that settles within a few days. For girth or length, filler, fat transfer or ligament release are the relevant options.

Q: How many P-Shot sessions are needed?

Usually 1–3 sessions, about 4 weeks apart , depending on your assessment and how you respond. When the P-Shot is combined with shockwave therapy, the PRP sessions are scheduled alongside the shockwave course rather than as a separate programme.

Q: When can I have sex after a P-Shot?

Sexual activity is usually possible after 1–2 days , as advised at your visit. If you notice increasing pain or swelling, contact us before resuming.

Q: What are the side effects of a P-Shot?

Most men have only mild soreness, bruising or temporary swelling for 1–3 days. Because PRP comes from your own blood, an allergic reaction to the product itself is not expected. As with any injection, infection is possible though uncommon; increasing pain, spreading redness or fever should be reported promptly.

Q: Who should not have a P-Shot?

PRP is not suitable for men with a platelet disorder or low platelet count , an active infection, or cancer. Men taking anticoagulants need an individual discussion first and should never stop their medication without their prescribing doctor.

Q: Can I have a P-Shot during a short trip to Istanbul?

Yes. The procedure takes about 30–45 minutes and has little downtime, so it fits into a short stay once the assessment is done. If it is combined with a shockwave course, the schedule is planned around those sessions. Our international patient team can help with timing.

The P-Shot uses platelet-rich plasma (PRP), prepared from your own blood and injected into the penis, to support erectile function and tissue quality. It is quick, done after numbing, and often paired with shockwave therapy. It is also widely oversold. At Veneta in Nişantaşı we offer it with two clear statements up front: it is not a size-enlargement treatment, and international urology guidelines still regard PRP for erectile dysfunction as investigational. Here is what that means in practice.

Last updated: October 2026

At a Glance

Treatment time

≈ 30–45 minutes in total

Anaesthesia

Numbing cream ± local block

Sessions

Usually 1–3, ≈ 4 weeks apart

Downtime

Mild soreness or bruising for 1–3 days

Sexual activity

Usually after 1–2 days, as advised

Evidence status

Investigational for ED

What the P-Shot Is — and What It Is Not

Platelets are the blood cells best known for helping wounds close. They also carry growth factors involved in tissue repair and in the formation of new blood vessels. PRP is your own plasma with a higher-than-normal concentration of platelets, and the idea behind the P-Shot is that delivering it into the penis may support the tissue and its blood supply — the same principle used when PRP is applied to skin or hair.

It is not a way to make the penis bigger. Any fullness afterwards is temporary swelling from the injections and settles within days. Nor is it a cure for erectile dysfunction, or a substitute for finding out what is causing the problem. For girth, see penis thickening.

How Platelet-Rich Plasma Is Prepared

A small blood sample is taken from your arm, much like a routine blood test. It is spun in a sterile tube in a centrifuge, which separates the blood into layers: red cells settle at the bottom, and the plasma above them is collected with its platelets concentrated. The PRP is drawn into fine syringes and used straight away.

Because PRP comes from your own blood, there is no foreign substance and no allergy to the product itself — although, as with any injection, the procedure is not low-risk. Preparation systems also differ in the platelet concentration they produce, which is one reason published studies are hard to compare.

Who Might Consider a P-Shot

A P-Shot is a supporting option, not a first-line treatment.

Mild to moderate ED

Men with mild to moderate erectile dysfunction, once the cause has been assessed, who want to explore options beyond tablets.

As part of a shockwave plan

Most often, PRP is added to a course of Li-ESWT shockwave therapy, which has a stronger evidence base for mild vasculogenic ED.

Men who accept the evidence status

Men who understand that PRP for ED is still investigational and are comfortable choosing it on that basis.

Not if your goal is size

The P-Shot does not lengthen or thicken the penis, and we do not offer it as an enlargement treatment.

Not before the cause is known

ED can be an early sign of cardiovascular disease, diabetes or low testosterone. These are looked for first.

The P-Shot Procedure, Step by Step

The whole visit takes about 30–45 minutes.

Assessment beforehand

History, the IIEF-5 erectile function questionnaire and relevant blood tests, so that PRP is never used in place of treating an underlying cause.

Numbing

A numbing cream is applied to the shaft and glans; a local anaesthetic block can be added for extra comfort.

Blood sample and preparation

While the cream takes effect, a small blood sample is taken and centrifuged to produce the platelet-rich plasma.

Injection

With a very fine needle, the PRP is injected at several points along the shaft and into the glans. This takes only a few minutes.

Aftercare and next steps

You leave with written aftercare instructions. If a further session is planned, it is usually about four weeks later.

The Evidence: An Honest Status Report

Early studies and a few small randomised trials suggest that PRP may improve erectile function in men with mild to moderate ED. That is encouraging, but it is not proof: the trials are small, preparation methods differ and long-term data are limited.

For that reason, international urology guidelines still regard PRP for erectile dysfunction as investigational — not yet established as a standard treatment. By comparison, PDE5 tablets are the established first-line treatment, and Li-ESWT is listed by the European Association of Urology as an option for mild vasculogenic ED.

We think it is fair to offer the P-Shot to well-informed men, but not to market it as a breakthrough or a cure, and we do not quote success percentages. Your IIEF-5 score before and after treatment is how we judge whether it has helped you.

P-Shot Alone, Shockwave Therapy, or Both?

	P-Shot alone	Li-ESWT alone	Combination
How it works	Growth factors from your own platelets	Acoustic pulses that stimulate new small blood vessels	Both, aimed at blood supply and tissue quality
Sessions	Usually 1–3, ≈ 4 weeks apart	Typically 6–12, 1–2 per week	A shockwave course, with PRP sessions scheduled alongside
Anaesthesia	Numbing cream ± local block	None	Numbing for PRP sessions only
Downtime	Soreness or bruising for 1–3 days	None	As for PRP, on injection days
Evidence	Investigational	EAU guideline option for mild vasculogenic ED	Less studied than either alone
Typical role	Rarely a first choice on its own	The main treatment for suitable men	An add-on when combining approaches

None of these changes penis size. Tablets can be continued alongside either treatment.

Aftercare After a P-Shot

Same dayMild swelling and a feeling of fullness are normal — swelling, not enlargement. Everyday activities and work can continue.
Days 1–2Sexual activity is usually possible after 1–2 days, as advised at your visit. Keep the area clean.
Days 1–3Mild soreness or bruising settles; we advise which simple painkillers to use if needed.
≈ 4 weeksThe next session, if your plan includes more than one.
Follow-upYour response is reviewed with the IIEF-5 questionnaire, in person or remotely.

Who Should Not Have a P-Shot

Because PRP depends on healthy platelets and involves injections, it is not suitable for everyone. Please tell us if any of the following applies:

A platelet disorder or a low platelet count.
Blood-thinning medication (anticoagulants) — discussed individually; do not stop it without your prescribing doctor.
An active infection, in the genital area or elsewhere.
Cancer, current or under treatment.
After treatment, contact us promptly about increasing pain, spreading redness, fever or swelling that worsens instead of settling.

How Veneta Approaches the P-Shot

Assessment first: cardiovascular, diabetic and hormonal causes of ED are looked for before any injection.
Honest consent: the investigational status of PRP for ED is explained and written into your plan.
Never sold for size: we do not offer the P-Shot as an enlargement treatment.
Combined thoughtfully: usually alongside shockwave therapy, and only when it adds something to your plan.
Measured response: IIEF-5 before and after, so the result is judged on more than impression.
Discretion and written 2026 pricing: a private first contact without photos and a clear written plan. See also our men's intimate health guide.

Related Procedures

Options frequently discussed alongside this procedure:

From the Blog: Men's Health

Frequently Asked Questions

Does the P-Shot make the penis bigger?

No. The P-Shot is not a size-enlargement treatment. Any fullness after the injections is temporary swelling that settles within a few days. For girth or length, filler, fat transfer or ligament release are the relevant options.

Is the P-Shot proven to work for erectile dysfunction?

Not in the way established treatments are. Early studies and a few small randomised trials suggest benefit in mild to moderate ED, but international urology guidelines still regard PRP for ED as investigational. We offer it on that basis, explain the status clearly and measure your response with the IIEF-5 questionnaire.

Does the P-Shot hurt?

A numbing cream is applied first, and a local anaesthetic block can be added, so most men feel brief pressure or a sting rather than significant pain. Mild soreness or bruising for 1–3 days afterwards is common and usually needs nothing more than simple painkillers.

How many P-Shot sessions are needed?

Usually 1–3 sessions, about 4 weeks apart, depending on your assessment and how you respond. When the P-Shot is combined with shockwave therapy, the PRP sessions are scheduled alongside the shockwave course rather than as a separate programme.

Can the P-Shot be combined with shockwave therapy?

Yes, and this is how it is most often used. Li-ESWT aims to stimulate new small blood vessels; PRP aims to support tissue quality. The combination is less studied than either treatment on its own, so we recommend it only when it adds something to your individual plan.

When can I have sex after a P-Shot?

Sexual activity is usually possible after 1–2 days, as advised at your visit. If you notice increasing pain or swelling, contact us before resuming.

What are the side effects of a P-Shot?

Most men have only mild soreness, bruising or temporary swelling for 1–3 days. Because PRP comes from your own blood, an allergic reaction to the product itself is not expected. As with any injection, infection is possible though uncommon; increasing pain, spreading redness or fever should be reported promptly.

Who should not have a P-Shot?

PRP is not suitable for men with a platelet disorder or low platelet count, an active infection, or cancer. Men taking anticoagulants need an individual discussion first and should never stop their medication without their prescribing doctor.

How long do the effects of a P-Shot last?

This has not been established by large studies — part of why PRP for ED is still considered investigational. Any benefit appears gradually rather than immediately and varies between men. We review your response with the IIEF-5 questionnaire and discuss further sessions only if there has been a measurable improvement.

Can I have a P-Shot during a short trip to Istanbul?

Yes. The procedure takes about 30–45 minutes and has little downtime, so it fits into a short stay once the assessment is done. If it is combined with a shockwave course, the schedule is planned around those sessions. Our international patient team can help with timing.

This page provides general medical information and does not replace a medical assessment. PRP for erectile dysfunction is considered investigational; results vary and cannot be guaranteed, and suitability is decided by the physician after evaluation.

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