Hand, Knee & Elbow Mesotherapy: Improving Thin, Crepey Skin — Istanbul
Hand, knee and elbow mesotherapy is a course of tiny injections of hyaluronic acid (HA), polynucleotides or vitamins into the skin to improve thin, dry or crepey skin. It targets skin quality; lost volume is treated with filler, and sun spots with IPL, laser or peels. Veneta in Nişantaşı offers it after an assessment by a physician.
Last updated: October 2026
At a Glance
Type
Micro-injections into the dermis
Methods
HA boosters, polynucleotides, vitamin cocktails
Sessions
Usually 3–4, 2–4 weeks apart
Results
Gradual; maintenance about every 6 months
Downtime
Bumps, redness or bruising for a few days
Evidence
Controlled hand trials of HA boosters; limited otherwise
What Is Hand, Knee and Elbow Mesotherapy?
With age and sun, the skin and fat on the back of the hand thin, giving a crepe-like, wrinkled look; bones, tendons, veins and sun spots show more. Skin above the knees can sag and turn crepey, and skin over the knees and elbows can be darker and slightly rough, with friction and family history thought to play a role.
Mesotherapy means many small injections into the skin. Here it uses HA skin boosters, polynucleotides (purified DNA from salmon or trout) or cocktails of vitamins and amino acids.
Evidence varies: HA boosters have randomised split-hand studies, and polynucleotides have randomised trials, mainly on the face. Evidence for vitamin cocktails is limited, and data for knees and elbows are thin.
Mesotherapy Methods and Alternatives
| Method | How it works | Typical use |
|---|---|---|
| HA skin booster | Hyaluronic acid microdroplets bind water | Thin, crepey skin on the hands |
| Polynucleotides | DNA fragments thought to support repair | Thin, less elastic skin; caution with fish allergy |
| Vitamin cocktail | Vitamins and amino acids, often with HA | Mild dryness; limited evidence |
| PRP | Your own platelet concentrate | Wrinkled, sun-damaged skin; small studies only |
| Hand filler | HA or a biostimulator restores volume | Visible veins and tendons |
| IPL, peels, RF microneedling | Target pigment or heat deeper skin | Sun spots; laxity above the knees |
What It Treats — and What It Doesn’t
- Crepey skin on the hands: HA boosters have controlled trials here, and one is labelled for the backs of the hands.
- Crepey skin above the knees: mesotherapy data are thin; RF microneedling has been studied for sagging there.
- Darker, rough knees and elbows: friction may play a role; urea or lactic acid creams and less friction help modestly in some cases.
- Velvety dark patches may be acanthosis nigricans, linked to diabetes and obesity: a dermatologist should check them first.
- Sun spots: IPL or peels, after a dermatologist checks them.
- Visible veins and tendons: a volume problem for hand filler.
Who It Suits — and Who Should Wait
- Suits: adults wanting gradual improvement in thin, dry or crepey skin.
- Wait: during pregnancy or breastfeeding, or with infection or skin disease in the area.
- Allergies: HA, lidocaine or streptococcal proteins (HA boosters); fish (polynucleotides).
- Medical history: some labels rule out bleeding disorders, keloids or autoimmune disease; blood thinners are discussed first.
- Darker skin: keloid history is checked; injections and IPL can leave darker patches, so IPL suits lighter skin better.
How the Treatment Works at Veneta
Assessment
A physician checks skin quality, volume and spots; any suspicious spot is diagnosed by a dermatologist first, and you receive a written plan.
Numbing
Numbing cream can be applied; some HA boosters also contain lidocaine for comfort.
Micro-injections
A fine needle places small droplets into the dermis; small bumps and redness are expected.
Aftercare and follow-up
Avoid strong sun and extreme cold until swelling settles, and ask before laser or peels on the area. Sessions repeat every 2–4 weeks, then results are reviewed.
Body Contouring Treatments: Average Prices in Istanbul
Average Istanbul market prices compiled in October 2026, for orientation. Your price is confirmed after your consultation.
| Treatment | Unit | Average price | Typical range |
|---|---|---|---|
| Double chin fat-dissolving injection | per session | 7,000 TRY≈ €125 | 3,500–24,000 TRY≈ €65–€430 |
| Cryolipolysis (fat freezing) | per area | 10,000 TRY≈ €180 | 5,000–14,000 TRY≈ €90–€250 |
| Cellulite treatment | per session | 6,000 TRY≈ €105 | 4,000–15,000 TRY≈ €70–€270 |
| Hand, knee or elbow mesotherapy | per session | 7,500 TRY≈ €135 | 4,000–15,000 TRY≈ €70–€270 |
Average Istanbul prices compiled in October 2026, for orientation only. Your personal price depends on the product, the amount and the plan agreed at your consultation. Euro amounts are approximate, converted at 55.86 TRY = 1 EUR.
Results and Other Options
Results are gradual and temporary; Galderma’s label for its HA booster reports improvement for up to 6 months, with maintenance generally every 6 months.
Skin boosters and PRP also target skin quality. Sun spots respond to Lumecca IPL or peels, and sagging above the knees has been studied with RF microneedling, the technology behind Morpheus8. Daily broad-spectrum SPF 30 or higher on the backs of the hands helps prevent new sun damage.
Related treatments
Frequently Asked Questions
Does hand mesotherapy work?
How many sessions of hand, knee or elbow mesotherapy do I need?
How long do mesotherapy results last?
Does hand mesotherapy hurt, and will I bruise?
Can mesotherapy lighten sun spots or dark knees and elbows?
What affects the cost of hand, knee or elbow mesotherapy?
This page is general information and does not replace a medical consultation. Whether hand, knee or elbow mesotherapy suits you is decided by our physicians after an assessment.
Free Consultation — Hand, Knee & Elbow Mesotherapy in Istanbul
Send us a WhatsApp message or book a video call; the consultation is free. You receive a written plan with the method, number of sessions and price before treatment.
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